Piperacillin Tazobactam Injections

Piperacillin & Tazobactam For Injections

Rs 350 / Vial

Strength: 4.5 gm
Injection Site: IV
Composition: Piperacillin(4g) + Tazobactam(0.5g)
Brand: Yashipiptaz
Form: Injection
Prescription Required: Yes

Composition:	Each vial contains: piperacillin sodium USP, Eq. to piperacillin 4 g, tazobactam sodium, Eq. to tazobactam 0.5 g
Pharmacological classification:	Antibacterial
Mechanism of action:	Piperacillin, a broad spectrum, semisynthetic penicillin exerts bactericidal activity by inhibition of both septum and cell wall synthesis. Tazobactam, a beta-lactam structurally related to penicillins, is an inhibitor of many beta- lactamases, which commonly cause resistance to penicillins and cephalosporins but it does not inhibit AmpC enzymes or metallo beta-lactamases. Tazobactam extends the antibiotic spectrum of Piperacillin to include many beta-lactamase- producing bacteria that have acquired resistance to Piperacillin alone.
Indications and usage:	Yashipiptaz is used in the management of neutropenic patients with fever suspected to be due to a bacterial infection. Yashipiptaz is indicated for the treatment of the following infections in adults and children over 2 years of age Adults and adolescents: Severe pneumonia including hospital-acquired and ventilator-associated pneumonia Complicated urinary tract infections (including pyelonephritis) Complicated intra-abdominal infections Complicated skin and soft tissue infections (including diabetic foot infections) Children 2 to 12 years of age: Complicated intra-abdominal infections
Dosage and administration:	Yashipiptaz is administered by intravenous injection (over 30 minutes). The dose and frequency of Yashipiptaz depends on the severity and localization of the infection and expected pathogens. Adult and adolescent patients: For Infections: The usual dose of 4g piperacillin /0.5g tazobactam is given every eight hours. For nosocomial pneumonia & bacterial infections in neutropenic patients: Recommended dose of 4g piperacillin /0.5g tazobactam is every six hours. This regimen may also be applicable to treat patients with other indicated infections when particularly severe. For patients on haemodialysis, one additional dose of piperacillin/tazobactam 2g/0.25g should be administered following each dialysis period. No dose adjustment is required for the elderly with normal renal function or creatinine clearance values above 40 mL/min. Children: YASHIPIPTAZ is not recommended for children below 2 years age. Neutropenic children with fever suspected due to bacterial infections: 80mg Piperacillin/10mg tazobactam per kg body weight, every six hours; not to exceed the maximum 4g /0.5g per dose over 30 minutes. Complicated intra-abdominal infections: 100mg piperacillin/12.5mg tazobactam per kg body weight, every eight hours; not to exceed the maximum 4g/0.5g per dose over 30 minutes. Creatinine Clearance = 50 mg/mL: 70mg piperacillin/8.75mg tazobactam per kg body weight, every eight hours. For children on haemodialysis, one additional dose of 40mg piperacillin /5mg tazobactam per kg should be administered following each dialysis period.