The Yashidine 5 (Procyclidine hydrochloride) is a synthetic antispasmodic compound with low toxic chemical composition.
It helps to cure symptomatic treatment of Parkinsonism (paralysis agitans) and extrapyramidal dysfunction that is caused by tranquilizer therapy.
Procyclidine hydrochloride is water-soluble, tasteless and white crystalline substance that is chemically abbreviated as α-cyclohexyl-α-phenyl-1-pyrrolidinepropanol hydrochloride.
The tablets can be consumed orally as per the prescription of doctor. It is available in the market under the hydrochloride.
Each uncoated tablet contains: procyclidine hydrochloride BP 5 mg
Procyclidine hydrochloride has an atropine-like action and exerts an antispasmodic effect on smooth muscle. It is potent mydriatic and inhibits salvation. It has no sympathetic ganglion-blocking activity in doses as high as 4 mg/kg as measured by the lack of inhibition of the response of the nictitating membrane to preganglionic electrical stimulation.
Yashidine 5 is indicated in the treatment of parkinsonism including the post- encephalitic, arteriosclerotic and idiopathic types. Partial control of the Parkinsonism symptoms is usual therapeutic accomplishment. Procyclidine hydrochloride is usually more efficacious in the relief of rigidity than tremor, but tremor, fatigue, weakness and sluggishness are frequently beneficially influenced. It can be substituted for all the previous medications in mild and moderate cases. For the control of more severe cases, other drugs may be added to procyclidine therapy as indications warrant.
Procyclidine Hydrochloride should not be used in angle-closure glaucoma although simple type glaucomas do not appear to be adversely affected.
Adverse reactions include dryness of mouth, mydriasis, blurring of vision, giddiness, lightheadedness and gastrointestinal disturbances such as nausea, vomiting, epigastric distress and constipation. Occasionally an allergic reaction such as skin rash may occur. Felling of muscular weakness may occur.
The usual dose of yashidine 5 for initial treatment is 2.5 mg administered three times daily after meals. If well tolerated, this dose may be gradually increased to 5 mg three times a day. In most cases excellent results may be obtained with 10 to 20 mg daily.