Thioridazine Hydrochloride Tablets Manufacturer from Thane

Thioridazine Hydrochloride Tablets

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Well-formulated and precise array of thioridazine tablets is offered to our clients. It is a phenothiazine group antipsychotic drug that is used for the treatment of...

Well-formulated and precise array of thioridazine tablets is offered to our clients. It is a phenothiazine group antipsychotic drug that is used for the treatment of psychosis and schizophrenia. Thioridazine Hcl/ Hydrochloride tab is delivered with 100 mg strength capacity.

Composition:	Thioridazine hydrochloride USP 100 mg,
ATC CODE:	N05AC02
Therapeutic category:	Antipsychotic drug belonging to the phenothiazine drug group
Pharmacology:	Effects apparently caused by dopamine receptor blocking in CNS.
Pharmacokinetics:	Absorption: more than 95% bound to plasma proteins. Metabolism: metabolized by CYP2D6, main active metabolite is mesoridazine. Elimination: plasma half-life is approximately 4 to 10 h.
Indications and usage:	Management of schizophrenia
Dosage & administration:	As directed by the physician Adults: The usual starting dose for adult schizophrenic patients is 50 mg to 100 mg three times a day, with a gradual increase to a maximum of 800 mg daily if necessary. Once effective control of symptoms has been achieved, the dosage may be reduced gradually to determine the minimum maintenance dose. The total daily dosage ranges from 200 mg to 800 mg, divided into two to four doses. Pediatric Patients: For pediatric patients with schizophrenia who are unresponsive to other agents, the recommended initial dose is 0.5 mg/kg/day given in divided doses. Dosage may be increased gradually until optimum therapeutic effect is obtained or the maximum dose of 3 mg/kg/day has been reached.
Contraindications:	Thioridazine hydrochloride tablet use should be avoided in combination with other drugs that are known to prolong the QTc interval and in patients with congenital long QT syndrome or a history of cardiac arrhythmias. Thioridazine is contraindicated in severe CNS depression or comatose states from any cause including drug induced CNS depression. It should also be noted that hypertensive or hypotensive heart disease of extreme degree is a contraindication of phenothiazine administration. Co-administration of drugs that inhibit P450 2D6 with thioridazine and the use of thioridazine in patients known to have reduced activity of P450 2D6 are contraindicated.
Warning & precautions:	Thioridazine hydrochloride is not approved for the treatment of elderly patients with dementia- related psychosis due to increased risk of mortality. Thioridazine should only be used in patients who have not shown improvement with or are unable to take other medicines. In schizophrenic patients with epilepsy, anticonvulsant medication should be maintained during treatment with thioridazine. pigmentary retinopathy due to taking larger than recommended doses, characterized by diminution of visual acuity, brownish coloring of vision and impairment of night vision, may occur. The possibility of this complication may be reduced by remaining within the recommended limits of dosage. Caution is recommended where patients are participating in activities requiring complete mental alertness for example driving or operating machineries.